Isolation of cloned cDNA encoding mammalian ornithine decarboxylase.

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منابع مشابه

Regulation of mammalian ornithine decarboxylase.

17 Melvin, M. A. L. and Keir, H. M. (1978) Expt. Cell Res. 111,231-236 18 Melvin, M. A. L. and Keir, H. M. (1979) Biochem. SOC. Trans. 7, 689-691 19 Wallace, H. M. and Keir, H. M. (1981) Biochim. Biophys. Acta 676,25-30 20 Melvin, M. A. L., Wallace, H. M. and Keir, H. M. (1980) Physiol. Chem. Phys. 12, 431-439 21 Coleman, C. S. and Wallace, H. M. (1990) 'Biochem. SOC. Trans. 18, 1228-1229 22 Wa...

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Sir: In the course of searching for inhibitors of mammalian ornithine decarboxylase (ODC), an active compound was isolated from the culture broth of an unidentified fungus and identified as citrinin, a known antibiotic1,2). Citrinin showed cytotoxicity in vitro to mouse leukemia cells. Structurally related compounds were examined for possible inhibition of ODC and cytotoxicity, and we found tha...

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Isolation and expression of a human ornithine decarboxylase gene.

We have isolated a human ornithine decarboxylase (ODC) gene from a leukocyte genomic DNA library in order to examine the mechanisms involved in the regulation of ODC gene expression in normal and neoplastic cell growth. Nucleotide sequence analysis shows that the human ODC gene in clone ODC709-A2 consists of 12 exons which encode a protein identical to that inferred from a human ODC cDNA sequen...

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Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme

Rat antizyme gene expression requires programmed, ribosomal frameshifting. A novel autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines. Antizyme binds to, and destabilizes, ornithine decarboxylase, a key enzyme in polyamine synthesis. Rapid degradation ensues, thus completing a regulatory circuit. In vitro experiments with a fusion ...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1984

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.81.12.3645